What Are Normal Cobalt And Chromium Levels?
Interpreting serum cobalt and chromium levels The laboratory reference range for cobalt is < 12 nmol/L and for chromium is 1 – 8 nmol/L.
What are normal chromium levels in blood?
Normal Results
Serum chromium level normally is less than or equal to 1.4 micrograms/liter (µg/L) or 26.92 nanomoles/L (nmol/L). Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test result.
What are toxic levels of chromium and cobalt?
DePuy Orthopedics, Inc. released a report saying that concentrations higher than 7 parts per billion (ppb) of cobalt and/or chromium are of concern.
What is the normal range for cobalt?
A cobalt concentration <1.8 μg/L indicates a normal amount of cobalt exposure. A cobalt concentration ≥1.8 μg/L indicates high cobalt exposure and risk of systemic toxicity.
What is a toxic level of cobalt?
Excessive cobalt can produce systemic toxicity affecting multiple organ systems. Adverse effects related to cobalt toxicity can occur at levels of 7-10 μg/L or more. Previously, cobalt toxicity has been seen in the form of pulmonary disease in those who inhaled cobalt dust while drilling or polishing.
What is a toxic level of chromium?
Chromium(III) is poorly absorbed in humans; most dietary chromium is excreted in the urine. The threshold for acute oral toxicity is 1900–3300 mg/kg.
What are symptoms of too much chromium?
Health Risks from Excessive Chromium
According to isolated case reports, chromium supplements might cause weight loss, anemia, thrombocytopenia, liver dysfunction, renal failure, rhabdomyolysis, dermatitis, and hypoglycemia [73,74].
What are symptoms of high cobalt?
Usually you have to be exposed to high levels of cobalt for weeks to months to have symptoms.
Symptoms
- Cardiomyopathy (a problem where your heart becomes big and floppy and has problems pumping blood)
- Deafness.
- Nerve problems.
- Ringing in the ears (tinnitus)
- Thickening of the blood.
- Thyroid problems.
- Vision problems.
How do you remove cobalt from your body?
One method of treating ASR Hip Replacement patients with high levels of chromium and cobalt in their blood is chelation therapy. The process involves the administration of chelating agents—the most common of which is ethylenediaminetetraacetic acid (EDTA)—to remove the poisonous metals from the body.
What happens if you have too much cobalt?
Cobalt is toxic to the heart muscle. It can cause heart muscle disease (toxic cardiomyopathy) after too much exposure. An increase in red blood cells (polycythemia) may be a symptom of too much cobalt. Not treating this issue can cause congestive heart failure.
What is a cobalt blood test for?
Blood cobalt levels can be used in the assessment of occupational exposure or toxic ingestion. Symptoms associated with cobalt toxicity vary based on route of exposure and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough and dyspnea.
What is cobalt deficiency?
As a component of vitamin B12 it can cause anemia. The common symptoms due to acute cobalt deficiency are paleness, weakness, fatigue, loss of appetite, weight loss, and subsequent poor growth, shortness of breath, dizziness, scaly ears and watery discharge from the eyes.
How does cobalt affect the human body?
It can harm the eyes, skin, heart, and lungs. Exposure to cobalt may cause cancer. Workers may be harmed from exposure to cobalt and cobalt-containing products. The level of harm depends upon the dose, duration, and work being done.
What foods is cobalt in?
Cobalt forms part of the structure of vitamin B12.
Good food sources of cobalt include:
- fish.
- nuts.
- green leafy vegetables, such as broccoli and spinach.
- cereals, such as oats.
How long does it take cobalt to leave your system?
Elevated blood levels of cobalt and chromium ions can persist for at least 1 year after revision, especially in patients with high levels of exposure.
What products contain the most cobalt?
On a global basis, the leading use of cobalt is in rechargeable battery electrodes. Superalloys, which are used to make parts for gas turbine engines, are another major use for cobalt.
What causes high chromium levels in the body?
Smoking, eating and cooking with stainless steel utensils and cookware, and having chrome orthopedic devices implanted can all result in chromium exposures.
Adverse health effects associated with Cr(VI) exposure include occupational asthma, eye irritation and damage, perforated eardrums, respiratory irritation, kidney damage, liver damage, pulmonary congestion and edema, upper abdominal pain, nose irritation and damage, respiratory cancer, skin irritation, and erosion and
Is chromium cancerous?
Human studies have clearly established that inhaled chromium (VI) is a human carcinogen, resulting in an increased risk of lung cancer. Animal studies have shown chromium (VI) to cause lung tumors via inhalation exposure.
How do I get rid of excess chromium?
No proven antidote is available for chromium poisoning. Treatment in cases of acute high-level chromium exposure is usually supportive and symptomatic. Treatment consists of removal of the patient from further chromium exposure, reliance on the body’s naturally rapid clearance of the metal and symptomatic management.
What hormone does chromium most affect in the body?
hormone insulin
Chromium enhances the action of the hormone insulin. [1) It is also involved in the breakdown and absorption of carbohydrate, proteins, and fats.
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